This research activity focuses on the development of an in-situ laboratory that allows to experiment in the microscope. The objectives of this activity are a) to develop a number of sample holders (based on the needs of the ESTEEM partners) to allow advanced in-situ experiments, b) to make available to the partners and the users of the facilities the developed specimen holders and their manufacturing expertise. A higher control of the experiments should lean to developing standards in this field helping translating results into materials improvement, and making in-situ electron microscopy also more accessible for small companies.